A quarto was made by folding the paper or vellum twice
into four leaves or eight pages. It
would have been roughly half the size of a folio.
In this photo, the largest volume is a folio (folded once--if you recall an earlier post about that). The second largest is a quarto.
Photo from OSU libraries:
https://library.osu.edu/innovation-projects/omeka/exhibits/show/the-king-james-bible/sidebars
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